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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730911 Species: Homo sapiens RGD Object: Gene Symbol: NGFR Name: nerve growth factor receptor

Acc ID: CHEBI:3374 Term: capsaicin Definition: A capsaicinoid that has formula C18H27NO3. CasRN: 404-86-4 Chemical ID: MESH:D002211

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:3177	6480464	CTD	Capsaicin results in increased expression of NGFR protein	PMID:22150557
decreases expression	ISO	RGD:3177	6480464	CTD	Capsaicin results in decreased expression of NGFR mRNA	PMID:8971780
multiple interactions	ISO	RGD:3177	6480464	CTD	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein] Naproxen inhibits the reaction [Capsaicin results in increased expression of NGFR protein] Sumatriptan inhibits the reaction [Capsaicin results in increased expression of NGFR protein]	PMID:22150557