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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344 Species: Rattus norvegicus RGD Object: Gene Symbol: Abca1 Name: ATP-binding cassette, subfamily A (ABC1), member 1

Acc ID: CHEBI:3374 Term: capsaicin Definition: A capsaicinoid that has formula C18H27NO3. CasRN: 404-86-4 Chemical ID: MESH:D002211

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1332354	6480464	CTD	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein] [Capsaicin results in increased expression of ABCA1 protein] which results in decreased uptake of Cholesterol APOE affects the reaction [Capsaicin results in increased expression of ABCA1 protein] [Capsaicin results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol Cyclosporine affects the reaction [Capsaicin results in increased expression of ABCA1 protein] TRPV1 gene mutant form inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein] KT 5720 inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein]	PMID:21908651
increases response to substance	ISO	RGD:1332354	6480464	CTD	ABCA1 results in increased susceptibility to Capsaicin	PMID:21908651
increases expression	ISO	RGD:1332354	6480464	CTD	Capsaicin results in increased expression of ABCA1 protein	PMID:21908651