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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2327
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpbincreases activityISOCebpb (Mus musculus)6480464CTDCapsaicin results in increased activity of CEBPB proteinPMID:21250977
Cebpbmultiple interactionsISOCebpb (Mus musculus)6480464CTD[Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]PMID:21250977
Cebpbmultiple interactionsISOCEBPB (Homo sapiens)6480464CTD[CEBPB protein binds to GDF15 promoter] promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA]; Capsaicin promotes the reaction [CEBPB protein binds to ATF3 protein binds to GSK3B protein]; CEBPB mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]; CEBPB protein promotes the reaction [Capsaicin results in increased expression of GDF15 mRNA]PMID:20110283
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