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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552559
Species: Mus musculus
RGD Object: Gene
Symbol: Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trpv1affects response to substanceEXP 6480464CTDTRPV1 protein affects the susceptibility to CapsaicinPMID:15331673 PMID:17627983
Trpv1increases activityEXP 6480464CTDCapsaicin results in increased activity of TRPV1 proteinPMID:12196566 PMID:16319926 PMID:17038422 PMID:18579526 PMID:20383154 PMID:21246380 PMID:21908651
Trpv1increases expressionEXP 6480464CTDCapsaicin results in increased expression of TRPV1 mRNA; Capsaicin results in increased expression of TRPV1 proteinPMID:19798065 PMID:21908651
Trpv1increases response to substanceEXP 6480464CTDTRPV1 protein results in increased susceptibility to Capsaicin; TRPV1 results in increased susceptibility to CapsaicinPMID:17347480 PMID:18203709 PMID:19878665 PMID:20712533
Trpv1multiple interactionsEXP 6480464CTD5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; CALCA protein affects the reaction [TRPV1 protein results in increased susceptibility to Capsaicin]; Capsaicin binds to and results in increased activity of TRPV1 protein; capsazepine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; CYBB protein affects the reaction [TRPV1 protein results in increased susceptibility to Capsaicin]; Linolenic Acids inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; RARRES2 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; RTKI cpd inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]]; TAC1 protein affects the reaction [TRPV1 protein results in increased susceptibility to Capsaicin]; TRPV1 gene mutant form inhibits the reaction [Capsaicin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; TRPV1 gene mutant form inhibits the reaction [Capsaicin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; TRPV1 gene mutant form inhibits the reaction [Capsaicin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]]; TRPV1 gene mutant form inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein]; TRPV1 gene mutant form inhibits the reaction [Capsaicin results in increased abundance of Reactive Oxygen Species]; TRPV1 gene mutant form inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein]; TRPV1 gene mutant form inhibits the reaction [Capsaicin results in increased expression of TNFRSF1A protein]; TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]; TRPV1 mutant form inhibits the reaction [Capsaicin results in increased abundance of Reactive Oxygen Species]; TRPV1 protein affects the reaction [Capsaicin results in increased abundance of Calcium]; TRPV1 protein affects the reaction [Capsaicin results in increased transport of Calcium]; TRPV1 results in decreased susceptibility to [Capsaicin co-treated with Tetradecanoylphorbol Acetate]; U 0126 inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]]PMID:12196566 PMID:17038422 PMID:17825279 PMID:17881535 PMID:18203709 PMID:18249134 PMID:19531269 PMID:19878665 PMID:20383154 PMID:20660715 PMID:20712533 PMID:21908651
Trpv1affects bindingISOTrpv1 (Rattus norvegicus)6480464CTDCapsaicin binds to TRPV1 proteinPMID:12237342 PMID:15601931
Trpv1affects bindingISOTRPV1 (Homo sapiens)6480464CTDCapsaicin binds to TRPV1 proteinPMID:11606325
Trpv1affects localizationISOTrpv1 (Rattus norvegicus)6480464CTDCapsaicin affects the localization of TRPV1 proteinPMID:17353553
Trpv1affects response to substanceISOTrpv1 (Rattus norvegicus)6480464CTDTRPV1 protein affects the susceptibility to CapsaicinPMID:18331834 PMID:18508045
Trpv1affects response to substanceISOTRPV1 (Homo sapiens)6480464CTDTRPV1 protein affects the susceptibility to Capsaicin; TRPV1 protein polymorphism affects the susceptibility to Capsaicin analogPMID:17110039 PMID:19056576
Trpv1decreases expressionISOTrpv1 (Rattus norvegicus)6480464CTDCapsaicin results in decreased expression of TRPV1 mRNA; Capsaicin results in decreased expression of TRPV1 proteinPMID:14975683 PMID:16788306 PMID:18079164 PMID:24746025
Trpv1decreases expressionISOTRPV1 (Homo sapiens)6480464CTDCapsaicin results in decreased expression of TRPV1 mRNA; Capsaicin results in decreased expression of TRPV1 proteinPMID:14987252
Trpv1decreases response to substanceISOTRPV1 (Homo sapiens)6480464CTDTRPV1 protein mutant form results in decreased susceptibility to Capsaicin; TRPV1 results in decreased susceptibility to CapsaicinPMID:17110039 PMID:21310942
Trpv1increases activityISOTrpv1 (Rattus norvegicus)6480464CTDCapsaicin results in increased activity of TRPV1; Capsaicin results in increased activity of TRPV1 proteinPMID:11140687 PMID:11358970 PMID:12886029 PMID:15363968 PMID:15471852 PMID:15781048 PMID:15854744 PMID:16901936 PMID:17038422 PMID:17392452 PMID:17984664 PMID:18331834 PMID:18617618 PMID:19537933 PMID:21950613 PMID:23264033
Trpv1increases activityISOTRPV1 (Homo sapiens)6480464CTDCapsaicin analog results in increased activity of TRPV1 protein; Capsaicin results in increased activity of TRPV1; Capsaicin results in increased activity of TRPV1 proteinPMID:11606325 PMID:12569099 PMID:12886029 PMID:16793902 PMID:17018028 PMID:17392452 PMID:17913835 PMID:18804451 PMID:19429182 PMID:19566590 PMID:19959817 PMID:21056583 PMID:21343315 PMID:21984481 PMID:22566028 PMID:27545873 PMID:28790335 PMID:29054683 PMID:29658714 PMID:30424709 PMID:30636360 PMID:31096838
Trpv1increases expressionISOTrpv1 (Rattus norvegicus)6480464CTDCapsaicin results in increased expression of TRPV1 mRNA; Capsaicin results in increased expression of TRPV1 proteinPMID:16278290 PMID:18752301 PMID:20712533
Trpv1increases response to substanceISOTRPV1 (Homo sapiens)6480464CTDTRPV1 protein results in increased susceptibility to Capsaicin; TRPV1 protein results in increased susceptibility to Capsaicin analogPMID:21343315 PMID:29658714
Trpv1multiple interactionsISOTrpv1 (Rattus norvegicus)6480464CTD1-Methyl-3-isobutylxanthine promotes the reaction [Capsaicin results in increased activity of TRPV1]; 2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; 2,4-bis(4'-fluorophenethylamino)-6-(3'-(N,N-dimethylamino)propylamino)-1,3,5-triazine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; 3-amino-5-((2-((2-methoxyethyl)amino)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)quinoxalin-2(1H)-one inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP promotes the reaction [Capsaicin results in increased activity of TRPV1]; [Capsaicin binds to and affects the activity of TRPV1 protein] which results in increased secretion of Adenosine Triphosphate; [Capsaicin results in increased activity of TRPV1 protein] which results in increased transport of Calcium; [Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium; [Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Cobalt; [Capsaicin results in increased activity of TRPV1] which results in increased uptake of Calcium; Acrylamide analog inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; Amitriptyline inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; benzimidazole analog inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; Bupivacaine affects the reaction [Capsaicin results in increased activity of TRPV1 protein]; Butyrates promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Butyrates promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Cadmium inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Calcium affects the reaction [Capsaicin inhibits the reaction [TRPV1 protein affects the susceptibility to Capsaicin]]; Calcium affects the reaction [mustard oil inhibits the reaction [TRPV1 protein affects the susceptibility to Capsaicin]]; Capsaicin binds to and results in increased activity of TRPV1 protein; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TRPV1 mRNA]; Capsaicin promotes the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; Capsaicin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]; Capsaicin promotes the reaction [TRPV1 protein binds to TRPV1 protein]; capsazepine inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Cobalt]; capsazepine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; chelerythrine inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein]; Cobalt inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1]; Copper inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Docosahexaenoic Acids promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Eicosapentaenoic Acid inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; Estradiol inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; Fulvestrant inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; gamma-Linolenic Acid inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1]; iodoresiniferatoxin inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein]; JYL 1421 inhibits the reaction [Capsaicin binds to TRPV1 protein]; JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; KJM 429 inhibits the reaction [Capsaicin binds to TRPV1 protein]; Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; MCS-18 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; N-((4-(((3-(6-((2-amino-1,3-benzothiazol-4-yl)oxy)pyrimidin-4-yl)) -6-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-fluorophenyl)methanesulfonamide inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; Nickel inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Octoxynol inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Cobalt]; Serotonin promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased transport of Calcium]; STAT1 mutant form inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein]; Tamoxifen inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]]; Tamoxifen inhibits the reaction [Estradiol inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]]; tert-butyl-2-(6-((2-(acetylamino)-1,3-benzothiazol-4-yl)oxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenylcarbamate inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; Tetracaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; TRPV1 protein affects the reaction [Capsaicin results in increased secretion of CALCA protein]PMID:11140687 PMID:11358970 PMID:11930156 PMID:12237342 PMID:12886029 PMID:15363968 PMID:15471852 PMID:15615864 PMID:15854744 PMID:16135784 PMID:16901936 PMID:16926503 PMID:17038422 PMID:17392452 PMID:17590514 PMID:17984664 PMID:18172555 PMID:18178321 PMID:18550765 PMID:18617618 PMID:18752301 PMID:19399481 PMID:19537933 PMID:19860742 PMID:20712533 PMID:21950613 PMID:23264033
Trpv1multiple interactionsISOTRPV1 (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine promotes the reaction [Capsaicin results in increased activity of TRPV1]; 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP promotes the reaction [Capsaicin results in increased activity of TRPV1]; [Capsaicin binds to and results in increased activity of TRPV1 protein] which results in increased abundance of Calcium; [Capsaicin binds to TRPV1 protein] which results in increased uptake of Calcium; [Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium; [Capsaicin results in increased activity of TRPV1 protein] which results in increased import of Calcium; [Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium; [Capsaicin results in increased activity of TRPV1] which results in increased uptake of Calcium; BDKRB2 affects the reaction [Capsaicin results in increased activity of TRPV1 protein]; BDKRB2 affects the reaction [KNG1 protein promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; Cannabidiol inhibits the reaction [[Capsaicin binds to TRPV1 protein] which results in increased uptake of Calcium]; Cannabidiol inhibits the reaction [Capsaicin binds to TRPV1 protein]; Capsaicin binds to and results in increased activity of TRPV1 protein; Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]; Capsaicin promotes the reaction [TRPV1 protein results in increased activity of CASP3 protein]; Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]; capsazepine inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; capsazepine inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; capsazepine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Phosphatidylinositol 4,5-Diphosphate affects the reaction [Capsaicin results in increased activity of TRPV1 protein]]; capsazepine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1]; Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; EDN1 protein promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Egtazic Acid inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]; iodoresiniferatoxin inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; KNG1 protein promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Phosphatidylinositol 4,5-Diphosphate affects the reaction [Capsaicin results in increased activity of TRPV1 protein]; PRKCE protein affects the reaction [F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]]; Rimonabant inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; Tetradecanoylphorbol Acetate inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; TRPV1 affects the reaction [Capsaicin results in increased expression of IGF1 mRNA]; TRPV1 affects the reaction [Capsaicin results in increased expression of IGF1R mRNA]; TRPV1 inhibits the reaction [Capsaicin results in increased expression of and results in increased activity of MMP9 protein]; TRPV1 promotes the reaction [Capsaicin results in increased uptake of Calcium]; TRPV1 protein promotes the reaction [Capsaicin results in increased expression of IL6 mRNA]; TRPV1 protein promotes the reaction [Capsaicin results in increased expression of IL6 protein]; Xenon inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]PMID:11278420 PMID:11606325 PMID:12569099 PMID:12886029 PMID:15363968 PMID:15615864 PMID:16597917 PMID:16793902 PMID:17306835 PMID:17442041 PMID:17913835 PMID:18230619 PMID:18769453 PMID:19429182 PMID:19602228 PMID:21056583 PMID:21310942 PMID:22566028 PMID:28790335 PMID:31096838
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