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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10370 Species: Mus musculus RGD Object: Gene Symbol: Cnr1 Name: cannabinoid receptor 1 (brain)

Acc ID: CHEBI:3374 Term: capsaicin Definition: A capsaicinoid that has formula C18H27NO3. CasRN: 404-86-4 Chemical ID: MESH:D002211

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:2369	6480464	CTD	Capsaicin results in increased activity of CNR1 protein	PMID:11408034
multiple interactions	EXP		6480464	CTD	CNR1 protein affects the reaction [Capsaicin results in increased secretion of CALCA protein]	PMID:18987195
affects response to substance	EXP		6480464	CTD	CNR1 protein affects the susceptibility to Capsaicin	PMID:18987195