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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520 Species: Mus musculus RGD Object: Gene Symbol: Cyp19a1 Name: cytochrome P450, family 19, subfamily a, polypeptide 1

Acc ID: CHEBI:33216 Term: bisphenol A Definition: A bisphenol that has formula C15H16O2. CasRN: 80-05-7 Chemical ID: MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1606587	6480464	CTD	bisphenol A affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]	PMID:22120136
multiple interactions	ISO	RGD:1606587	6480464	CTD	bisphenol A inhibits the reaction [FSHB results in increased expression of CYP19A1 mRNA] bisphenol A inhibits the reaction [FSHB results in increased expression of CYP19A1 protein]	PMID:20064783
decreases expression	ISO	RGD:1606587	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 mRNA	PMID:22327052 PMID:22120136
increases expression	EXP		6480464	CTD	bisphenol A results in increased expression of CYP19A1 mRNA bisphenol A results in increased expression of CYP19A1 protein	PMID:21182934 PMID:21123812
affects expression	ISO	RGD:2457	6480464	CTD	bisphenol A affects the expression of CYP19A1 mRNA	PMID:22285353
multiple interactions	ISO	RGD:2457	6480464	CTD	bisphenol A inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]	PMID:22120136
decreases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 mRNA	PMID:18191889 PMID:22120136
decreases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 protein	PMID:22285353
decreases expression	ISO	RGD:1606587	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 mRNA	PMID:22120136 PMID:22327052
increases expression	EXP		6480464	CTD	bisphenol A results in increased expression of CYP19A1 protein bisphenol A results in increased expression of CYP19A1 mRNA	PMID:21123812 PMID:21182934
decreases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 mRNA	PMID:22120136 PMID:18191889
multiple interactions	ISO	RGD:2457	6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein] anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein] PD 98059 inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein] SB 239063 inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein] N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]	PMID:20096755
decreases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 mRNA	PMID:18191889
multiple interactions	ISO	RGD:2457	6480464	CTD	[bisphenol A results in decreased expression of CYP19A1 mRNA] which affects the abundance of Estradiol	PMID:18191889
increases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in increased expression of CYP19A1 mRNA	PMID:20096755
decreases activity	ISO	RGD:1606587	6480464	CTD	bisphenol A results in decreased activity of CYP19A1 protein	PMID:12849724
increases activity	ISO	RGD:1606587	6480464	CTD	bisphenol A results in increased activity of CYP19A1 protein	PMID:12849724
multiple interactions	EXP		6480464	CTD	bisphenol A affects the reaction [CYP19A1 affects the expression of GDF9 mRNA] bisphenol A affects the reaction [CYP19A1 affects the expression of BMP15 mRNA] bisphenol A affects the reaction [CYP19A1 affects the expression of IGF1 mRNA] bisphenol A affects the reaction [CYP19A1 affects the expression of IGF1R mRNA]	PMID:11985600
increases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in increased expression of CYP19A1 protein	PMID:20821433
multiple interactions	EXP		6480464	CTD	[bisphenol A co-treated with Diethylhexyl Phthalate] results in increased expression of CYP19A1 mRNA [bisphenol A co-treated with Diethylhexyl Phthalate] results in increased expression of CYP19A1 protein	PMID:22828881
decreases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 protein	PMID:22285353 PMID:23405234
decreases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in decreased expression of CYP19A1 mRNA	PMID:18191889 PMID:22120136 PMID:23528252
increases expression	ISO	RGD:2457	6480464	CTD	bisphenol A results in increased expression of CYP19A1 mRNA	PMID:20096755 PMID:23326527 PMID:23405234