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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tertdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TERT mRNAPMID:25181051 PMID:30816183 PMID:32528016
Tertincreases expressionEXP 6480464CTDbisphenol A results in increased expression of TERT mRNAPMID:34947998
Tertaffects methylationISOTert (Mus musculus)6480464CTDbisphenol A affects the methylation of TERT promoterPMID:27334623
Tertdecreases activityISOTERT (Homo sapiens)6480464CTDbisphenol A results in decreased activity of TERT proteinPMID:29192164
Tertincreases expressionISOTERT (Homo sapiens)6480464CTDbisphenol A results in increased expression of TERT mRNAPMID:15368248 PMID:36572933
Tertmultiple interactionsISOTERT (Homo sapiens)6480464CTD1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [bisphenol A results in decreased activity of TERT protein]; 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bisphenol A results in decreased activity of TERT protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in decreased activity of TERT protein]; [bisphenol A co-treated with Fulvestrant] results in decreased methylation of TERT gene; G36 compound inhibits the reaction [bisphenol A results in decreased activity of TERT protein]; U 0126 inhibits the reaction [bisphenol A results in decreased activity of TERT protein]PMID:29192164 PMID:31601247
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