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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631409
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90aa1
Name: heat shock protein 90 alpha family class A member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90aa1affects expressionEXP 6480464CTDbisphenol A affects the expression of HSP90AA1 mRNAPMID:30903817
Hsp90aa1increases expressionEXP 6480464CTDbisphenol A results in increased expression of HSP90AA1 mRNA; bisphenol A results in increased expression of HSP90AA1 proteinPMID:15229138 PMID:25181051 PMID:30816183
Hsp90aa1affects expressionISOHSP90AA1 (Homo sapiens)6480464CTDbisphenol A affects the expression of HSP90AA1 mRNAPMID:30903817
Hsp90aa1decreases expressionISOHsp90aa1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of HSP90AA1 proteinPMID:35999755
Hsp90aa1increases expressionISOHSP90AA1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of HSP90AA1 proteinPMID:34186270
Hsp90aa1increases expressionISOHsp90aa1 (Mus musculus)6480464CTDbisphenol A results in increased expression of HSP90AA1 mRNA; bisphenol A results in increased expression of HSP90AA1 proteinPMID:12927369 PMID:28641223
Hsp90aa1multiple interactionsISOHSP90AA1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HSP90AA1 mRNAPMID:28628672
Hsp90aa1multiple interactionsISOHsp90aa1 (Mus musculus)6480464CTDbisindolylmaleimide I inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 mRNA]; bisphenol A results in increased expression of and affects the localization of HSP90AA1 protein; fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90AA1 protein]PMID:11568360 PMID:12927369
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