GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp2 | affects expression | EXP | | 6480464 | CTD | bisphenol A affects the expression of MMP2 mRNA | PMID:25181051 | Mmp2 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of MMP2 mRNA | PMID:34947998 | Mmp2 | increases methylation | EXP | | 6480464 | CTD | bisphenol A results in increased methylation of MMP2 gene | PMID:28505145 | Mmp2 | decreases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of MMP2 mRNA; bisphenol A results in decreased expression of MMP2 protein | PMID:31230753 PMID:31675489 PMID:32981897 PMID:34186270 | Mmp2 | decreases expression | ISO | Mmp2 (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased expression of MMP2 mRNA; bisphenol A results in decreased expression of MMP2 protein | PMID:30303745 PMID:33930482 | Mmp2 | decreases methylation | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased methylation of MMP2 gene | PMID:31601247 | Mmp2 | increases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of MMP2 mRNA; bisphenol A results in increased expression of MMP2 protein | PMID:19956873 PMID:24997338 PMID:25312822 PMID:26407941 PMID:27038254 PMID:27685785 PMID:28466560 PMID:28844962 PMID:29275510 PMID:33683587 | Mmp2 | increases expression | ISO | Mmp2 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of MMP2 mRNA; bisphenol A results in increased expression of MMP2 protein | PMID:28903498 PMID:30951980 PMID:35479511 | Mmp2 | multiple interactions | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of MMP2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; [bisphenol A co-treated with Fulvestrant] results in decreased methylation of MMP2 gene; bisphenol A results in increased expression of and results in increased activity of MMP2 protein; ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP2 mRNA]; ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP2 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of MMP2 protein] | PMID:19956873 PMID:24997338 PMID:25312822 PMID:26407941 PMID:27038254 PMID:28844962 PMID:31601247 | Mmp2 | multiple interactions | ISO | Mmp2 (Mus musculus) | 6480464 | CTD | [bisphenol A co-treated with Tretinoin] results in decreased expression of MMP2 mRNA; bisphenol A results in increased expression of and results in increased activity of MMP2 protein; CREB3 protein affects the reaction [bisphenol A results in decreased expression of MMP2 mRNA]; CREB3 protein affects the reaction [bisphenol A results in decreased expression of MMP2 protein] | PMID:25862758 PMID:30951980 PMID:33930482 | |
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