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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb4affects expressionEXP 6480464CTDbisphenol A affects the expression of ERBB4 mRNAPMID:30816183
Erbb4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ERBB4 mRNAPMID:25181051
Erbb4increases expressionEXP 6480464CTDbisphenol A results in increased expression of ERBB4 mRNAPMID:29097150 PMID:34858468
Erbb4increases methylationEXP 6480464CTDbisphenol A results in increased methylation of ERBB4 genePMID:28505145
Erbb4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ERBB4 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of ERBB4 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] affects the expression of ERBB4 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of ERBB4 mRNAPMID:25607892
Erbb4decreases expressionISOErbb4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of ERBB4 mRNAPMID:30951980 PMID:32156529
Erbb4increases methylationISOERBB4 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of ERBB4 genePMID:31601247
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