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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62028
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b1
Name: nuclear receptor subfamily 0, group B, member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b1affects expressionEXP 6480464CTDbisphenol A affects the expression of NR0B1 mRNAPMID:25181051
Nr0b1affects methylationISONr0b1 (Mus musculus)6480464CTDbisphenol A affects the methylation of NR0B1 promoterPMID:27334623
Nr0b1decreases expressionISONr0b1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of NR0B1 mRNAPMID:25270620 PMID:30245210 PMID:34585602
Nr0b1increases expressionISONr0b1 (Mus musculus)6480464CTDbisphenol A results in increased expression of NR0B1 mRNAPMID:32156529
Nr0b1multiple interactionsISONR0B1 (Homo sapiens)6480464CTD[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NR0B1 protein modified form]PMID:28751236
Nr0b1multiple interactionsISONr0b1 (Mus musculus)6480464CTD[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]PMID:30245210
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