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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619930
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11affects expressionEXP 6480464CTDbisphenol A affects the expression of ABCB11 mRNAPMID:32145629
Abcb11decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ABCB11 mRNAPMID:25181051
Abcb11increases expressionISOAbcb11 (Mus musculus)6480464CTDbisphenol A results in increased expression of ABCB11 mRNAPMID:30245210 PMID:32156529 PMID:33221593
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of ABCB11 genePMID:31601247
Abcb11multiple interactionsISOAbcb11 (Mus musculus)6480464CTD[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ABCB11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]PMID:28433925 PMID:30245210
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