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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3641
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scnn1g
Name: sodium channel epithelial 1 subunit gamma
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scnn1gincreases expressionEXP 6480464CTDbisphenol A results in increased expression of SCNN1G mRNAPMID:25181051
Scnn1gdecreases expressionISOSCNN1G (Homo sapiens)6480464CTDbisphenol A results in decreased expression of SCNN1G mRNA; bisphenol A results in decreased expression of SCNN1G proteinPMID:27522653
Scnn1gdecreases expressionISOScnn1g (Mus musculus)6480464CTDbisphenol A results in decreased expression of SCNN1G proteinPMID:26283537
Scnn1gincreases methylationISOSCNN1G (Homo sapiens)6480464CTDbisphenol A results in increased methylation of SCNN1G genePMID:31601247
Scnn1gmultiple interactionsISOSCNN1G (Homo sapiens)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [bisphenol A results in decreased expression of SCNN1G protein]; Dexamethasone inhibits the reaction [bisphenol A results in decreased expression of SCNN1G mRNA]; Dexamethasone inhibits the reaction [bisphenol A results in decreased expression of SCNN1G protein]; fulvestrant inhibits the reaction [bisphenol A results in decreased expression of SCNN1G protein]; NR3C1 protein promotes the reaction [bisphenol A results in decreased expression of SCNN1G protein]PMID:27522653
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