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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2711
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a4
Name: solute carrier family 2 member 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a4affects expressionEXP 6480464CTDbisphenol A affects the expression of SLC2A4 mRNAPMID:25181051 PMID:32145629
Slc2a4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SLC2A4 mRNA; bisphenol A results in decreased expression of SLC2A4 proteinPMID:27836638 PMID:28153594 PMID:30816183 PMID:32339907 PMID:32528016 PMID:34165232 PMID:36291063 PMID:37570835
Slc2a4increases expressionEXP 6480464CTDbisphenol A results in increased expression of SLC2A4 mRNAPMID:24988533
Slc2a4increases methylationEXP 6480464CTDbisphenol A results in increased methylation of SLC2A4 genePMID:28505145
Slc2a4multiple interactionsEXP 6480464CTDbisphenol A results in decreased expression of and affects the localization of SLC2A4 protein; lithospermate B inhibits the reaction [bisphenol A results in decreased expression of SLC2A4 protein]; Resveratrol inhibits the reaction [bisphenol A results in decreased expression of SLC2A4 protein]PMID:23424204 PMID:28739533 PMID:34165232 PMID:37570835
Slc2a4decreases expressionISOSLC2A4 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of SLC2A4 proteinPMID:32175033
Slc2a4decreases expressionISOSlc2a4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of SLC2A4 mRNA; bisphenol A results in decreased expression of SLC2A4 proteinPMID:25637671 PMID:26779933 PMID:32623698 PMID:35489422
Slc2a4increases expressionISOSLC2A4 (Homo sapiens)6480464CTDbisphenol A results in increased expression of SLC2A4 mRNAPMID:27685785
Slc2a4increases expressionISOSlc2a4 (Mus musculus)6480464CTDbisphenol A results in increased expression of SLC2A4 proteinPMID:14707028 PMID:26923231
Slc2a4multiple interactionsISOSLC2A4 (Homo sapiens)6480464CTD[Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SLC2A4 proteinPMID:33836827
Slc2a4multiple interactionsISOSlc2a4 (Mus musculus)6480464CTD[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SLC2A4 mRNA; [Streptozocin co-treated with bisphenol A] results in decreased expression of SLC2A4 mRNAPMID:29935216 PMID:30665118
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