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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2666
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gata6
Name: GATA binding protein 6
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata6decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GATA6 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Gata6increases expressionEXP 6480464CTDbisphenol A results in increased expression of GATA6 mRNAPMID:33296240
Gata6multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GATA6 promoterPMID:23359474
Gata6affects methylationISOGata6 (Mus musculus)6480464CTDbisphenol A affects the methylation of GATA6 promoterPMID:27334623
Gata6decreases expressionISOGata6 (Mus musculus)6480464CTDbisphenol A results in decreased expression of GATA6 mRNAPMID:22687993
Gata6increases expressionISOGata6 (Mus musculus)6480464CTDbisphenol A results in increased expression of GATA6 mRNAPMID:30951980 PMID:32156529
Gata6multiple interactionsISOGATA6 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of GATA6 genePMID:31601247
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