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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2448
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsl
Name: cathepsin L
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctslaffects expressionEXP 6480464CTDbisphenol A affects the expression of CTSL mRNAPMID:30903817
Ctsldecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CTSL mRNAPMID:30816183 PMID:32145629 PMID:34947998
Ctslmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of CTSL mRNAPMID:36041667
Ctslaffects expressionISOCTSL (Homo sapiens)6480464CTDbisphenol A affects the expression of CTSL mRNAPMID:30903817
Ctsldecreases expressionISOCTSL (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CTSL proteinPMID:31675489
Ctslincreases expressionISOCtsl (Mus musculus)6480464CTDbisphenol A results in increased expression of CTSL mRNAPMID:34585602
Ctslincreases expressionISOCTSL (Homo sapiens)6480464CTDbisphenol A results in increased expression of CTSL mRNA; bisphenol A results in increased expression of CTSL proteinPMID:27685785 PMID:37567409
Ctslmultiple interactionsISOCtsl (Mus musculus)6480464CTD[Dextran Sulfate co-treated with bisphenol A] results in decreased expression of CTSL proteinPMID:35999755
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