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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2247
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna2d1
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna2d1affects expressionEXP 6480464CTDbisphenol A affects the expression of CACNA2D1 mRNAPMID:25181051
Cacna2d1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CACNA2D1 mRNAPMID:34947998
Cacna2d1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of CACNA2D1 genePMID:28505145
Cacna2d1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA2D1 mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA2D1 mRNAPMID:25607892
Cacna2d1decreases expressionISOCacna2d1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CACNA2D1 mRNAPMID:31250031 PMID:32156529
Cacna2d1increases methylationISOCACNA2D1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of CACNA2D1 genePMID:31601247
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