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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2143
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp4
Name: aquaporin 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of AQP4 mRNAPMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
Aqp4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of AQP4 mRNA; [bisphenol A co-treated with Testosterone] results in decreased expression of AQP4 mRNAPMID:26496021 PMID:36041667
Aqp4decreases expressionISOAqp4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of AQP4 mRNAPMID:32156529 PMID:33221593
Aqp4increases expressionISOAqp4 (Mus musculus)6480464CTDbisphenol A results in increased expression of AQP4 mRNAPMID:30951980
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