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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtaffects expressionEXP 6480464CTDbisphenol A affects the expression of AGT mRNAPMID:30903817
Agtdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of AGT mRNAPMID:25181051
Agtincreases expressionEXP 6480464CTDbisphenol A results in increased expression of AGT mRNA; bisphenol A results in increased expression of AGT proteinPMID:30677511 PMID:32145629 PMID:38027817
Agtmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of AGT mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of AGT protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased expression of AGT mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased expression of AGT protein]; [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein]; bisphenol A inhibits the reaction [Estradiol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of and results in increased secretion of AGT protein modified form]]; Captopril inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of AGT mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of AGT protein]PMID:30677511 PMID:32319667 PMID:38027817
Agtaffects expressionISOAGT (Homo sapiens)6480464CTDbisphenol A affects the expression of AGT mRNAPMID:30903817
Agtincreases expressionISOAgt (Mus musculus)6480464CTDbisphenol A results in increased expression of AGT mRNA; bisphenol A results in increased expression of AGT proteinPMID:25103225 PMID:30951980
Agtincreases expressionISOAGT (Homo sapiens)6480464CTDbisphenol A results in increased expression of AGT mRNA; bisphenol A results in increased expression of AGT proteinPMID:27685785 PMID:30677511 PMID:36828454
Agtincreases methylationISOAgt (Mus musculus)6480464CTDbisphenol A results in increased methylation of AGT promoterPMID:27312807
Agtmultiple interactionsISOAGT (Homo sapiens)6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased expression of AGT mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of AGT mRNA]PMID:30677511
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