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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tcf7l2
Name: transcription factor 7 like 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tcf7l2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TCF7L2 mRNAPMID:25181051 PMID:36803626
Tcf7l2increases expressionEXP 6480464CTDbisphenol A results in increased expression of TCF7L2 mRNAPMID:33296240 PMID:34858468
Tcf7l2increases methylationEXP 6480464CTDbisphenol A results in increased methylation of TCF7L2 genePMID:28505145
Tcf7l2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of TCF7L2 mRNA; [bisphenol A co-treated with Testosterone] results in increased expression of TCF7L2 mRNAPMID:26496021
Tcf7l2affects methylationISOTCF7L2 (Homo sapiens)6480464CTDbisphenol A affects the methylation of TCF7L2 genePMID:31601247
Tcf7l2decreases expressionISOTcf7l2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of TCF7L2 mRNAPMID:30951980
Tcf7l2increases expressionISOTcf7l2 (Mus musculus)6480464CTDbisphenol A results in increased expression of TCF7L2 mRNAPMID:32365465 PMID:34585602
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