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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrp5
Name: LDL receptor related protein 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp5decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LRP5 mRNAPMID:25381574 PMID:25963729 PMID:30816183 PMID:33296240 PMID:34947998
Lrp5increases expressionEXP 6480464CTDbisphenol A results in increased expression of LRP5 mRNAPMID:25181051 PMID:32145629
Lrp5multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of LRP5 mRNA; Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]PMID:25963729 PMID:26496021
Lrp5affects methylationISOLRP5 (Homo sapiens)6480464CTDbisphenol A affects the methylation of LRP5 genePMID:31601247
Lrp5decreases expressionISOLrp5 (Mus musculus)6480464CTDbisphenol A results in decreased expression of LRP5 mRNAPMID:33221593
Lrp5increases expressionISOLrp5 (Mus musculus)6480464CTDbisphenol A results in increased expression of LRP5 mRNAPMID:32156529
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