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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307513
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pmel
Name: premelanosome protein
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pmeldecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PMEL mRNAPMID:34947998
Pmelincreases expressionEXP 6480464CTDbisphenol A results in increased expression of PMEL mRNAPMID:25181051
Pmelincreases expressionISOPMEL (Homo sapiens)6480464CTDbisphenol A results in increased expression of PMEL mRNAPMID:31715268
Pmelmultiple interactionsISOPMEL (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PMEL mRNAPMID:28628672
Pmelmultiple interactionsISOPmel (Mus musculus)6480464CTD[Dextran Sulfate co-treated with bisphenol A] results in decreased expression of PMEL proteinPMID:35999755
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