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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10458 Species: Mus musculus RGD Object: Gene Symbol: Cyp7a1 Name: cytochrome P450, family 7, subfamily a, polypeptide 1

Acc ID: CHEBI:33216 Term: bisphenol A Definition: A bisphenol that has formula C15H16O2. CasRN: 80-05-7 Chemical ID: MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	bisphenol A results in increased expression of CYP7A1 mRNA	PMID:17706920
multiple interactions	EXP		6480464	CTD	LHB protein affects the reaction [bisphenol A results in increased expression of CYP7A1 mRNA]	PMID:17706920
decreases expression	ISO	RGD:69210	6480464	CTD	bisphenol A results in decreased expression of CYP7A1 mRNA	PMID:23146750