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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:33083
Term: fluoranthene
Definition: An ortho- and peri-fused polycyclic arene consisting of a naphthalene and benzene unit connected by a five-membered ring.
Chemical ID: MESH:C007738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDfluoranthene results in decreased expression of ESR1 proteinPMID:18634860
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; fluoranthene binds to and results in increased activity of ESR1 protein; fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [fluoranthene promotes the reaction [Estradiol results in increased activity of ESR1 protein]]PMID:12441364 PMID:30980910 PMID:33049310
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