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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305332 Species: Rattus norvegicus RGD Object: Gene Symbol: Mdm2 Name: p53 E3 ubiquitin protein ligase

Acc ID: CHEBI:32692 Term: 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one Definition: A nitrosamine that has formula C10H13N3O2. CasRN: 64091-91-4 Chemical ID: MESH:C016583

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA	PMID:14600272 PMID:15890375
increases expression	EXP		6480464	CTD	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA	PMID:15890375 PMID:14600272
increases expression	EXP		6480464	CTD	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA	PMID:14600272 PMID:15890375 PMID:22484513
increases expression	EXP		6480464	CTD	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA	PMID:14600272 PMID:15890375 PMID:22484513 PMID:23052194