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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9affects expressionEXP 6480464CTDpirinixic acid affects the expression of CYP3A9 mRNAPMID:19483382
Cyp3a9decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of CYP3A9 mRNAPMID:19162173 PMID:19850644 PMID:22484513
Cyp3a9decreases expressionISOCyp3a13 (Mus musculus)6480464CTDpirinixic acid results in decreased expression of CYP3A13 mRNAPMID:19850644
Cyp3a9increases expressionISOCyp3a13 (Mus musculus)6480464CTDpirinixic acid results in increased expression of CYP3A13 mRNAPMID:18445702
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A5 mRNAPMID:19710929
Cyp3a9multiple interactionsISOCyp3a13 (Mus musculus)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYP3A13 mRNAPMID:19710929
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