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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68441 Species: Homo sapiens RGD Object: Gene Symbol: GABRE Name: gamma-aminobutyric acid (GABA) A receptor, epsilon

Acc ID: CHEBI:32509 Term: pirinixic acid Definition: An aryl sulfide that has formula C14H14ClN3O2S. CasRN: 50892-23-4 Chemical ID: MESH:C006253

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GABRE mRNA	PMID:19710929
multiple interactions	ISO	RGD:68442	6480464	CTD	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of GABRE mRNA]	PMID:17950772
decreases expression	ISO	RGD:68442	6480464	CTD	pirinixic acid results in decreased expression of GABRE mRNA	PMID:17950772