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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620460 Species: Rattus norvegicus RGD Object: Gene Symbol: Nphs1 Name: nephrosis 1, congenital, Finnish type (nephrin)

Acc ID: CHEBI:32509 Term: pirinixic acid Definition: An aryl sulfide that has formula C14H14ClN3O2S. CasRN: 50892-23-4 Chemical ID: MESH:C006253

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:732787	6480464	CTD	Mifepristone inhibits the reaction [pirinixic acid results in increased expression of NPHS1 mRNA] pirinixic acid promotes the reaction [IL1B protein results in increased expression of NPHS1 mRNA]	PMID:16288986
increases expression	ISO	RGD:732787	6480464	CTD	pirinixic acid results in increased expression of NPHS1 mRNA pirinixic acid results in increased expression of NPHS1 protein	PMID:16288986
increases stability	ISO	RGD:732787	6480464	CTD	pirinixic acid results in increased stability of NPHS1 mRNA	PMID:16288986