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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3639
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scnn1a
Name: sodium channel epithelial 1 subunit alpha
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scnn1adecreases expressionISOScnn1a (Mus musculus)6480464CTDpirinixic acid results in decreased expression of SCNN1A mRNAPMID:17950772 PMID:20813756 PMID:23811191
Scnn1amultiple interactionsISOScnn1a (Mus musculus)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SCNN1A mRNA; [pirinixic acid co-treated with PPARA] results in decreased expression of SCNN1A mRNA; PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SCNN1A mRNA]PMID:17950772 PMID:19710929 PMID:20813756
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