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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases expressionEXP 6480464CTDThioacetamide results in decreased expression of MMP9 mRNAPMID:19784758
Mmp9increases activityEXP 6480464CTDThioacetamide results in increased activity of MMP9 proteinPMID:30883860
Mmp9increases expressionEXP 6480464CTDThioacetamide results in increased expression of MMP9 mRNA; Thioacetamide results in increased expression of MMP9 proteinPMID:15095483 PMID:34492290
Mmp9increases secretionEXP 6480464CTDThioacetamide results in increased secretion of MMP9 proteinPMID:22899499
Mmp9multiple interactionsEXP 6480464CTDrebaudioside A inhibits the reaction [Thioacetamide results in increased activity of MMP9 protein]PMID:30883860
Mmp9increases activityISOMmp9 (Mus musculus)6480464CTDThioacetamide results in increased activity of MMP9 proteinPMID:28845018
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDThioacetamide results in increased expression of MMP9 mRNAPMID:28845018
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDACE2 gene mutant form promotes the reaction [Thioacetamide results in increased activity of MMP9 protein]; ACE2 gene mutant form promotes the reaction [Thioacetamide results in increased expression of MMP9 mRNA]PMID:28845018
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