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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1decreases expressionEXP 6480464CTDThioacetamide results in decreased expression of GSTM1 proteinPMID:12370186
Gstm1increases expressionEXP 6480464CTDThioacetamide results in increased expression of GSTM1 mRNAPMID:15497818
Gstm1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GSTM1 mRNA; Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in decreased expression of GSTM1 protein]PMID:12370186 PMID:23830814 PMID:28943392
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