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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347215 Species: Homo sapiens RGD Object: Gene Symbol: TIMP1 Name: TIMP metallopeptidase inhibitor 1

Acc ID: CHEBI:32497 Term: thioacetamide Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur. CasRN: 62-55-5 Chemical ID: MESH:D013853

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731433	6480464	CTD	IL10 protein inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]	PMID:16126171
multiple interactions	ISO	RGD:731433	6480464	CTD	KRT18 protein affects the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]	PMID:18395095
multiple interactions	ISO	RGD:731433	6480464	CTD	POMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of and results in increased activity of TIMP1 protein] POMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]	PMID:16511523
increases expression	ISO	RGD:731433	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:16511523 PMID:16126171 PMID:18395095
multiple interactions	ISO	RGD:621675	6480464	CTD	Cysteine inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA] Methionine inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]	PMID:15158331
multiple interactions	ISO	RGD:731433	6480464	CTD	[Thioacetamide co-treated with Ethanol] results in increased expression of TIMP1 protein	PMID:16780996
multiple interactions	ISO	RGD:621675	6480464	CTD	Nucleotides inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]	PMID:11925456
multiple interactions	ISO	RGD:621675	6480464	CTD	halofuginone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]	PMID:16489207
increases expression	ISO	RGD:621675	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:16489207 PMID:15158331 PMID:15464241
multiple interactions	ISO	RGD:621675	6480464	CTD	Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]	PMID:15464241
increases expression	ISO	RGD:621675	6480464	CTD	Thioacetamide results in increased expression of TIMP1 protein	PMID:11925456
increases expression	ISO	RGD:731433	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:16126171 PMID:16511523 PMID:18395095
increases expression	ISO	RGD:621675	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:15158331 PMID:15464241 PMID:16489207
multiple interactions	ISO	RGD:731433	6480464	CTD	CNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TIMP1 mRNA]	PMID:21863215
increases expression	ISO	RGD:731433	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:18395095 PMID:16126171 PMID:16511523
increases expression	ISO	RGD:621675	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:15158331 PMID:16489207 PMID:15464241
increases expression	ISO	RGD:621675	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:15464241 PMID:15158331 PMID:16489207
increases expression	ISO	RGD:621675	6480464	CTD	Thioacetamide results in increased expression of TIMP1 mRNA	PMID:16489207 PMID:15464241 PMID:15158331