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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007 Species: Homo sapiens RGD Object: Gene Symbol: CYP2E1 Name: cytochrome P450, family 2, subfamily E, polypeptide 1

Acc ID: CHEBI:32497 Term: thioacetamide Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur. CasRN: 62-55-5 Chemical ID: MESH:D013853

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10451	6480464	CTD	CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of IL6 mRNA] CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of NOS2 protein] CYP2E1 protein affects the reaction [Thioacetamide results in decreased expression of GPX1 mRNA] CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of TNF mRNA]	PMID:18374380
decreases expression	ISO	RGD:2475	6480464	CTD	Thioacetamide results in decreased expression of CYP2E1 mRNA	PMID:16297948
increases response to substance	ISO	RGD:10451	6480464	CTD	CYP2E1 protein results in increased susceptibility to Thioacetamide	PMID:18374380
multiple interactions	ISO	RGD:2475	6480464	CTD	Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]	PMID:20036707
increases expression	ISO	RGD:2475	6480464	CTD	Thioacetamide results in increased expression of CYP2E1 protein	PMID:20036707