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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2055
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra1a
Name: adrenoceptor alpha 1A
Acc ID: CHEBI:3223
Term: buspirone
Definition: An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Chemical ID: MESH:D002065
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra1amultiple interactionsEXP 6480464CTDBuspirone binds to and results in decreased activity of ADRA1A proteinPMID:16545797
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