GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rara | increases expression | EXP | | 6480464 | CTD | tamibarotene results in increased expression of RARA protein | PMID:19457078 | Rara | decreases response to substance | ISO | RARA (Homo sapiens) | 6480464 | CTD | RARA results in decreased susceptibility to tamibarotene | PMID:17611697 | Rara | multiple interactions | ISO | RARA (Homo sapiens) | 6480464 | CTD | tamibarotene inhibits the reaction [[KLF5 protein binds to [RARA protein binds to RXRA protein]] which binds to PDGFA promoter]; tamibarotene inhibits the reaction [[RARA co-treated with RXRA] promotes the reaction [KLF5 results in increased expression of PDGFA mRNA]]; tamibarotene inhibits the reaction [KLF5 protein binds to [RARA protein binds to RXRA protein]]; tamibarotene inhibits the reaction [RARA protein binds to PDGFA promoter] | PMID:16224062 | |
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