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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552559
Species: Mus musculus
RGD Object: Gene
Symbol: Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Acc ID: CHEBI:32111
Term: saccharin
Definition: A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Chemical ID: MESH:D012439
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trpv1multiple interactionsEXP 6480464CTDTRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin]PMID:18804451
Trpv1increases activityISOTRPV1 (Homo sapiens)6480464CTDSaccharin results in increased activity of TRPV1 proteinPMID:17567713 PMID:18804451
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