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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619930
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:32020
Term: pitavastatin
Definition: A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.
Chemical ID: MESH:C108475
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDpitavastatin results in decreased activity of ABCB11 proteinPMID:24014644
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTDpitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; pitavastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:15901796 PMID:24014644
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