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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2180
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp7b
Name: ATPase copper transporting beta
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp7baffects response to substanceISOATP7B (Homo sapiens)6480464CTDATP7B protein affects the susceptibility to oxaliplatinPMID:16773204
Atp7bdecreases expressionISOATP7B (Homo sapiens)6480464CTDoxaliplatin results in decreased expression of ATP7B mRNAPMID:16773204
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