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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3318
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Acc ID: CHEBI:3181
Term: bromocriptine
Definition: An indole alkaloid that has formula C32H40BrN5O5.
Chemical ID: MESH:D001971
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1bincreases activityEXP 6480464CTDBromocriptine results in increased activity of ABCB1B promoterPMID:9111066
Abcb1bincreases expressionEXP 6480464CTDBromocriptine results in increased expression of ABCB1B mRNAPMID:9111066
Abcb1bmultiple interactionsEXP 6480464CTDClozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Pertussis Toxin inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]PMID:9111066
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