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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionEXP 6480464CTDlead acetate results in decreased expression of NOS3 proteinPMID:30980911
Nos3increases expressionEXP 6480464CTDlead acetate results in increased expression of NOS3 proteinPMID:11454931 PMID:11729227
Nos3multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [lead acetate results in increased expression of NOS3 protein]; sodium bisulfide inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS3 protein]PMID:11454931 PMID:11729227 PMID:30980911
Nos3decreases expressionISONos3 (Mus musculus)6480464CTDlead acetate results in decreased expression of NOS3 proteinPMID:23501611 PMID:23855546
Nos3increases expressionISONOS3 (Homo sapiens)6480464CTDlead acetate results in increased expression of NOS3 proteinPMID:11230275
Nos3multiple interactionsISONos3 (Mus musculus)6480464CTDpuerarin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]PMID:23501611 PMID:23855546
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTDtempol inhibits the reaction [lead acetate results in increased expression of NOS3 protein]; U 74389F inhibits the reaction [lead acetate results in increased expression of NOS3 protein]PMID:11230275
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