GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | decreases expression | EXP | | 6480464 | CTD | lead acetate results in decreased expression of EGFR protein | PMID:17298174 | Egfr | increases phosphorylation | ISO | EGFR (Homo sapiens) | 6480464 | CTD | lead acetate results in increased phosphorylation of EGFR protein | PMID:19133285 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein]; EGFR mutant form inhibits the reaction [lead acetate results in increased activity of PRKCA protein]; EGFR mutant form inhibits the reaction [lead acetate results in increased phosphorylation of SRC protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein] | PMID:19133285 | |
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