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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737381 Species: Homo sapiens RGD Object: Gene Symbol: ADRA2A Name: adrenoceptor alpha 2A

Acc ID: CHEBI:3175 Term: brimonidine Definition: A quinoxaline that has formula C11H10BrN5. CasRN: 59803-98-4 Chemical ID: MESH:C015620

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Prazosin inhibits the reaction [Phenylephrine promotes the reaction [brimonidine binds to and results in increased activity of ADRA2A protein]] brimonidine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] brimonidine promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein] Yohimbine inhibits the reaction [brimonidine promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]]	PMID:10742289
multiple interactions	ISO	RGD:10098	6480464	CTD	brimonidine binds to and results in increased activity of ADRA2A protein	PMID:12598592
multiple interactions	ISO	RGD:2056	6480464	CTD	brimonidine binds to and results in increased activity of ADRA2A protein	PMID:12208771
multiple interactions	ISO	RGD:2056	6480464	CTD	brimonidine binds to and results in increased activity of ADRA2A protein	PMID:8397342 PMID:12208771
multiple interactions	ISO	RGD:2056	6480464	CTD	brimonidine binds to and results in increased activity of ADRA2A protein	PMID:12208771 PMID:8397342