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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737336 Species: Homo sapiens RGD Object: Gene Symbol: GRIA3 Name: glutamate receptor, ionotropic, AMPA 3

Acc ID: CHEBI:31746 Term: kainic acid Definition: A pyrrolidinecarboxylic acid that has formula C10H15NO4. CasRN: 487-79-6 Chemical ID: MESH:D007608

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:70958	6480464	CTD	Kainic Acid results in decreased expression of GRIA3 mRNA	PMID:7529610
increases expression	ISO	RGD:70958	6480464	CTD	Kainic Acid results in increased expression of GRIA3 mRNA	PMID:7529610
decreases expression	ISO	RGD:737337	6480464	CTD	Kainic Acid results in decreased expression of GRIA3 mRNA	PMID:21589914
multiple interactions	ISO	RGD:737337	6480464	CTD	celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]	PMID:21589914