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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620293
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ece1
Name: endothelin converting enzyme 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ece1multiple interactionsISOECE1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of ECE1 gene; [bisphenol S co-treated with Fulvestrant] results in increased methylation of ECE1 gene; [Fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNAPMID:19943105 PMID:31601247
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