GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | decreases expression | EXP | | 6480464 | CTD | eplerenone results in decreased expression of TGFB1 mRNA; eplerenone results in decreased expression of TGFB1 protein | PMID:18682491 | Tgfb1 | multiple interactions | EXP | | 6480464 | CTD | [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]] | PMID:18682491 PMID:27773435 | | ||||||||||||||||||||||
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