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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:31547
Term: eplerenone
Definition: A steroid acid ester that has formula C24H30O6.
Chemical ID: MESH:C414690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionEXP 6480464CTDEplerenone results in decreased expression of NOS3 mRNA; Eplerenone results in decreased expression of NOS3 proteinPMID:20571278
Nos3increases activityEXP 6480464CTDeplerenone results in increased activity of NOS3 proteinPMID:15974890
Nos3increases expressionEXP 6480464CTDeplerenone results in increased expression of NOS3 mRNAPMID:15974890
Nos3multiple interactionsEXP 6480464CTD[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNAPMID:20571278
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