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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:31530
Term: edaravone
Definition: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Chemical ID: MESH:C005435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTD[Edaravone co-treated with Chlorpyrifos] results in increased expression of NFE2L2 protein; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]PMID:25348283 PMID:30758894
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDEdaravone affects the localization of NFE2L2 proteinPMID:25422538
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