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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2892 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1r1 Name: interleukin 1 receptor, type I

Acc ID: CHEBI:31530 Term: edaravone Definition: A ring assembly that has formula C10H10N2O. CasRN: 89-25-8 Chemical ID: MESH:C005435

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	phenylmethylpyrazolone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA] phenylmethylpyrazolone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein]	PMID:18078833