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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:30958
Term: Sudan I
Definition: An azo compound that has formula C16H12N2O.
Chemical ID: MESH:C024336
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionEXP 6480464CTD1-phenylazo-2-naphthol results in increased expression of CYP1A2 mRNAPMID:26845733
Cyp1a2multiple interactionsEXP 6480464CTD1-phenylazo-2-naphthol affects the expression of and affects the activity of CYP1A2 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A2 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of CYP1A2 proteinPMID:26845733
Cyp1a2increases oxidationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphtholPMID:17159775
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDCYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]PMID:17159775
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