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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:30778
Term: gallic acid
Definition: A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.
Chemical ID: MESH:D005707
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9multiple interactionsEXP 6480464CTDGallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP9 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP9 protein]PMID:24309158
Mmp9decreases activityISOMMP9 (Homo sapiens)6480464CTDGallic Acid results in decreased activity of MMP9 proteinPMID:22387266
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDGallic Acid results in decreased expression of MMP9 mRNA; Gallic Acid results in decreased expression of MMP9 proteinPMID:22387266
Mmp9decreases expressionISOMmp9 (Mus musculus)6480464CTDGallic Acid results in decreased expression of MMP9 mRNAPMID:16304905
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of and results in increased secretion of MMP9 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]PMID:27087131 PMID:27634460
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